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Manuchair Ebadi Selected Research

1,2,3,4- tetrahydro- 1- (phenylmethyl)isoquinoline

5/20041-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.
11/2003Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells.
6/20031-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, induces dopaminergic cell death through apoptosis.

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Manuchair Ebadi Research Topics

Disease

23Parkinson Disease (Parkinson's Disease)
02/2014 - 01/2002
7Parkinsonian Disorders (Parkinsonism)
05/2008 - 11/2003
6Neuroblastoma
12/2008 - 10/2004
4Neurodegenerative Diseases (Neurodegenerative Disease)
01/2013 - 06/2003
2Alzheimer Disease (Alzheimer's Disease)
01/2014 - 11/2006
2Mitochondrial Diseases (Mitochondrial Disease)
12/2008 - 06/2003
2Tremor (Tremors)
11/2006 - 06/2002
1Deafness (Deaf Mutism)
09/2013
1Anosmia
09/2013
1Neoplasms (Cancer)
01/2013
1Infections
01/2013
1Cardiovascular Diseases (Cardiovascular Disease)
01/2013
1Synucleinopathies
01/2013
1Nervous System Diseases (Neurological Disorders)
11/2010
1Narcolepsy
11/2006
1Tourette Syndrome (Tourette's Syndrome)
11/2006
1Ischemia
11/2006
1Substance-Related Disorders (Drug Abuse)
03/2006
1Breast Neoplasms (Breast Cancer)
01/2006
1Vascular Diseases (Vascular Disease)
01/2006
1Acute Pain
01/2005
1Pathologic Processes
06/2003
1Necrosis
05/2003
1Pain (Aches)
09/2002

Drug/Important Bio-Agent (IBA)

9NeurotoxinsIBA
02/2014 - 06/2003
7alpha-SynucleinIBA
07/2008 - 05/2003
7MetallothioneinIBA
06/2008 - 01/2002
61- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
02/2014 - 06/2002
6Peroxynitrous Acid (Peroxynitrite)IBA
10/2006 - 06/2003
4Pharmaceutical PreparationsIBA
01/2013 - 11/2005
4Selegiline (E250)FDA LinkGeneric
12/2008 - 05/2003
4Proteins (Proteins, Gene)FDA Link
05/2008 - 06/2003
4salsolinolIBA
03/2007 - 11/2003
3Methamphetamine (Desoxyn)FDA LinkGeneric
11/2010 - 03/2006
3coenzyme Q10 (CoQ10)IBA
06/2006 - 03/2005
31-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA
05/2005 - 11/2003
31,2,3,4- tetrahydro- 1- (phenylmethyl)isoquinolineIBA
05/2004 - 06/2003
2Biomarkers (Surrogate Marker)IBA
09/2013 - 01/2013
2Free RadicalsIBA
12/2008 - 11/2005
2Reactive Oxygen Species (Oxygen Radicals)IBA
12/2008 - 05/2003
2Amphetamine (Amfetamine)FDA LinkGeneric
05/2008 - 08/2007
2MelatoninIBA
08/2007 - 01/2005
2NF-kappa B (NF-kB)IBA
03/2007 - 05/2003
2Dopamine (Intropin)FDA LinkGeneric
01/2006 - 06/2002
2Superoxide DismutaseIBA
06/2003 - 05/2003
1Metallothionein 3IBA
01/2014
1SynucleinsIBA
01/2013
1Free Radical ScavengersIBA
01/2013
1zinc thioneinIBA
12/2008
1Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)IBA
06/2008
1Dextroamphetamine (Dexedrine)FDA LinkGeneric
08/2007
1JNK Mitogen-Activated Protein KinasesIBA
03/2007
1ebselenIBA
11/2006
1BromidesIBA
07/2006
1Cocaine (Cocaine HCl)IBA
03/2006
1HomocysteineIBA
01/2006
1Estrogens (Estrogen)FDA Link
01/2006
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2006
1IonsIBA
03/2005
1ChloridesIBA
10/2004
1diethylenetriamineIBA
10/2004
1spermine nitric oxide complexIBA
10/2004
1linsidomineIBA
10/2004
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
06/2003
1Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA
06/2003
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
06/2003
1DNA (Deoxyribonucleic Acid)IBA
06/2003
1Hydroxyl RadicalIBA
06/2003
1Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2003
1Nitric Oxide Synthase (NO Synthase)IBA
06/2003
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
06/2003
1IronIBA
06/2003
1Adenosine Triphosphate (ATP)IBA
05/2003
1GuanosineIBA
05/2003
1Glutathione (Reduced Glutathione)IBA
05/2003
1Cytochromes c (Cytochrome c)IBA
05/2003
1Analgesics (Analgesic Drugs)IBA
09/2002
1UbiquinoneIBA
01/2002

Therapy/Procedure

1Radiotherapy
01/2013